View the Assembly LXX schedule below:




Thursday, November 11

Registration - 8:00 a.m.-5:00 p.m.
Rose Alumni House, 232 York Street
Assembly participants will check in and receive their packet of materials for the Assembly program. The packet will include the final program for the weekend, as well as name badges and other materials. Though it is a short walk up York Street to the Medical School, transportation to the sessions on Thursday will be provided.

Assembly Welcome - 9:30-9:45 a.m.
Assembly and AYA Chair Michael Madison '83 will welcome delegates and guests to the Assembly and share his thoughts on the rich history and exciting future of medicine at Yale.

Academic Excellence with a Billion-Dollar Budget - 9:45-10:45 a.m.
Research, education and patient care are the three missions of the Yale School of Medicine. With tuition and endowment together covering only 11% of the budget, revenues from research grants and patient care largely fuel the dynamic enterprise that is the medical school and help generate new knowledge about the human body and new ways of treating disease. Dean Robert Alpern will describe the unique environment that sets the medical school apart from other parts of the university and detail the strong bonds that connect Sterling Hall of Medicine to the Central Campus.

The Yale System of Medical Education - 11:00 a.m.-12:00 p.m.
Yale's distinct identity among medical schools is built on the principles and values of the Yale System of Medical Education. Respect for student initiative and maturity, close faculty mentoring, and a required thesis to promote scientific inquiry are all hallmarks of our unique learning environment.

Students are assessed based on their performance, but there is no class rank and efforts are made to minimize competition. Emphasis is placed on collaboration, self-directed learning, and the expectation that students take more than the usual responsibility for their education.

Richard Belitsky, M.D., Deputy Dean for Education, will moderate a panel that will highlight how these unique characteristics shape the futures of Yale Medical students. Panelists will include Nancy Angoff,

Associate Dean for Student Affairs, YSM Graduate 1990; Danny Balkin, M.D./Ph.D. Student; Alisse Hauspurg, M.D. Student, Class of 2012; and Max Laurans, Assistant Professor, Department of Neurosurgery, YSM Graduate 2003.


Lunch and New Delegate Orientation - 12:15-1:30 p.m.
Most Assembly participants will have gourmet boxed lunched in various spaces around the Medical School. In addition, the New Delegate Luncheon will provide an overview of the Assembly and the delegate role for new delegates. New delegates will have a ticket with more information on the luncheon and its location in their registration packet.


Genes, Genomes and the Future of Medicine - 2:00-3:00 p.m.
Richard P. Lifton, M.D., Ph.D.
Over the last 20 years, human genetic studies have been re-writing the textbooks of the basic causes of human disease. We are now at the dawn of another new era. Building upon the complete sequence of the human genome, spectacular reductions in the cost of DNA sequencing now point to a coming epoch of genetics and genomics based on identification of rare mutations that confer disease risk in individual patients. When the sequence of the first human genome was initiated, the cost to produce 1 million bases of sequence was $100,000. The recent development of new technologies that permit simultaneous sequencing of hundreds of millions of DNA templates have driven the cost to sequence 1 million bases to under $0.25.

This advance opens myriad opportunities for the use of DNA sequencing in gene discovery and clinical diagnosis. These are expected to impact the understanding of common and rare diseases in the near term, and to define the best therapeutic targets for new drug development.

It is also increasingly clear that the cost of DNA sequencing is fast approaching a threshold at which point it will become a routine part of the diagnostic armamentarium and increasingly dictate specific therapy. These considerations raise many critical questions. Who will benefit from comprehensive sequencing? When in life should this be done? How should we deal with uncertain results? How do we effectively communicate results to patients in ways that will improve health without inducing neurosis? These questions have far-reaching implications for education of health care professionals and patients as well as health and social policy.


Medicine at Yale Today and Tomorrow - 3:15-5:15 p.m.
Assembly participants will have the unique opportunity to learn more about some of the many areas of research and clinical care in medicine at Yale today from those who are creating the future of medicine. Each session will begin with a presentation and overview of work in the area currently being done at Yale as well a glimpse into the possible future. Following the presentations, tours of labs and other facilities and in many cases hands-on or behind the scenes experiences, will be directed by some of the world's leading doctors and researchers. This is a once-in-a-lifetime chance to see discovery and innovation in medicine in process! Please indicate the session you would like to attend on the registration form.


Helping Older Persons Preserve Their Independence

We are sorry, but this session is full and we are no longer accepting registrations.

Leo M. Cooney, Jr., M.D., Human Foundation Professor of Geriatric Medicine
The Yale Section of Geriatrics is devoted to keeping older individuals as functional and independent as possible. Faculty members have made nationally recognized contributions in the area of falls, delirium, maintaining functional abilities, driving problems, sleep disorders, and establishing goals of care for older individuals. One of the major clinical sites for the care of older individuals is the Dorothy Adler Geriatric Assessment Center. Participants will tour this center and meet with faculty members to discuss their efforts to keep older individuals as independent and functional as possible.

The Cellular Metabolism That Supports Long Healthy Life

We are sorry, but this session is full and we are no longer accepting registrations.

Tamas Horvath, Professor of Comparative Medicine and Neurobiology; Chair of Comparative Medicine; Professor Obstetrics and Gynecology
The leading causes of morbidity and mortality in the U.S. (according to the CDC) are: cardiovascular diseases, cancer, cerebrovascular diseases, Alzheimer's disease and diabetes. While seemingly diverse, these ailments share a fundamental similarity in that they are late onset disorders, generally occurring after the fourth, fifth and sixth decades of life. Therefore, it is logical that the emergence of these diseases is the consequence of chronic overworking of various tissues that over time, based upon genetic, epigenetic and environmentally triggered vulnerabilities, leads to the development of illnesses and eventual death. It is our hypothesis that the cellular energy metabolism of various tissues determines tissue and whole body health. Over nutrition (i.e., obesity) promotes the progression of all of the aforementioned diseases and accelerates death. Conversely, calorie restriction slows the advancement of all of these chronic ailments. Our laboratory focuses on the regulatory and molecular principles of this process. We recently identified a specific subset of brain cells that are fundamental to the manifestation of the beneficial effects of calorie restriction on health and lifespan. By furthering our understanding of how these cells govern the integrative physiology of the body, including peripheral tissue functions, immune responses, higher brain functions and neurodegeneration, we will be able to design targeted interventions for the promotion of a longer, healthier life by the suppression of tissue malignancies, cardiovascular impairments, metabolic disorders and neurodegeneration. There will be an opportunity to visit our laboratories to show the simple, mainly non-invasive approaches that we utilize to study these mechanisms.


The Social Brain in Autism: New Development, Diagnosis and Treatment
Fred Volkmar, Director, Yale Child Study Center
This session will focus on the developments in the diagnosis and treatment
of autism with an emphasis on new research findings and clinical implications. The Child Study Center has conducted work in this area since 1950. Recent research here has clarified aspects of the genetic and brain basis of these conditions as well as methods for improved early detection and diagnosis. Videos and other material will be used to illustrate some of the approaches taken in clarifying our understanding of the social brain in autism.


The Genetic Ballet of Making Antibodies: A Fragile Choreography That Can Lead to Cancer
David G. Schatz, Ph.D., Professor of Immunobiology; Professor of Molecular Biophysics and Biochemistry
Fighting infectious organisms (e.g., bacteria, viruses) is the job of the immune system, and antibody proteins are a key tool in this fight. To make antibodies, our immune cells must carry out complex genetic manipulations that rearrange and mutate parts of our chromosomes. Ironically, these mechanisms are both highly beneficial (combatting infections) and intrinsically dangerous-when they make mistakes, they cause damage to our chromosomes and can lead to the development of cancers known as leukemias and lymphomas. We will talk about my laboratory's efforts to understand how these genetic processes work and why they so often make mistakes and cause cancer. We will visit the laboratory where you will be able to see and use some of the tools of modern molecular biology and, using a microscope, see the different types of cells we use in our experiments. Yale undergraduate and graduate students will be on hand to discuss their research experiences, the process of discovery, and the importance of collaborations with other scientists.

Personalized Therapy of Cancer-How Molecular Profiling Will Lead to Improvements in Cancer Therapy
Tom Lynch, '82, '86 M.D., Jonathan and Richard Sackler Professor of Medicine, Director Yale Cancer Center, Physician-in-Chief Smilow Cancer Hospital
We know what cancer is-it is a disease caused by genes that abnormally drive the growth of cells. These cells grow in an uncontrolled manner and form tumors which then spread as metastases. In 2010 we are able, for the first time ever, to look into each patient's cancer-determine the genes that are abnormal and are driving the cancer-and then design treatments based on this understanding. In this session we will use three patient cases as examples of cancers where we profile the molecular changes and choose treatments based on these findings. We will tour the molecular profiling center in the Fitkin building and will then tour the Smilow Cancer Hospital which opened in 2009.

Breast Cancer Treatment: Where Are We Going?
Anees B. Chagpar, M.D., M.SC., M.A., M.P.H., FACS, FRCS (C), Director, Yale Breast Center at Smilow Cancer Hospital
The last quarter century has witnessed a significant metamorphosis in terms of breast cancer treatment. Radical disfiguring surgery has yielded to minimally invasive approaches, toxic chemotherapies have evolved into much more targeted regimens, and radiation therapy has become accelerated and more focused. Breast cancer is being diagnosed at earlier stages, and significant strides have been made in primary prevention of this disease. Yet much remains to be done. Join us as we discuss the evolution of multidisciplinary breast cancer management, explore exciting new research that is moving the field forward, and tour the state-of-the-art facilities at the Yale Breast Center at Smilow Cancer Hospital.


Delivering Safer Care: New Technologies and Approaches to Patient Safety
Edmund F. Funai, M.D., Professor of Obstetrics, Gynecology and Reproductive
Sciences; and Christian M. Pettker, M.D., Assistant Professor of Obstetrics, Gynecology and Reproductive Sciences

As medicine has proven more effective and powerful against complex diseases, the risks of failure and inadvertent harm have increased as well. We will review the hazards in hospital care in the U.S. today, and the reasons why some patients are subject to preventable harm. The session will use maternity care as an example of how of hospitals can be made safer, focusing on how Yale clinicians are leading the way in the effort to improve care for expectant mothers and their newborns. We will also cover the role of simulation in high-quality care, and will conduct high-fidelity simulation drills using a state of the art mannequin named NOELLE. Some participants will also get the opportunity to deliver a baby, albeit a plastic one.

How Safe is Your Backyard? Lyme Disease and Other Tick-Borne Infections
Erol Fikrig, M.D. Waldemar von Zedtwitz Professor of Medicine; Chief, Section of Infectious Diseases; and Investigator, Howard Hughes Medical Institute
Our research group studies the pathogenesis of infectious diseases transmitted by ticks and mosquitoes. These illnesses include Lyme disease, West Nile encephalitis, dengue fever, malaria and human anaplasmosis. Using molecular and immunologic techniques, we are developing new strategies to prevent and treat these important medical problems.

The Tiniest Hearts: The Biology of Congenital Heart Disease
Martina Brueckner, M.D., Associate Professor, Pediatrics and Genetics
The session will start with a brief presentation about congenital heart disease, the most common major birth defect. The talk will highlight how scientists at Yale are using state-of-the-art genetics and developmental biology to understand how the heart develops, and why it sometimes goes wrong. We will then see the clinic and catheterization lab where infants and children with heart disease are cared for at Yale. The observations made in the clinic will then inspire you to return to the lab, where members of the Yale Vertebrate Development Program will introduce you to frogs, mice and cells that provide a window into the biology underlying heart development and disease.

Childhood Obesity Research Program at Yale
Sonia Caprio, M.D., Professor of Pediatrics/Endocrinology and Mary Savoye, R.D., CD-N, Research Associate
We will present our research program on Childhood Obesity and its metabolic complications. Dr. Caprio will describe studies that are ongoing to understand: 1) Why Obese kids develop Type 2 Diabetes; and adult disease, and 2) The effect of simple sugar on brain feeding centers using functional MRI in obese kids. Mary Savoye will present her program on effects of a family based healthy lifestyle program on childhood obesity.


Set It and Forget It? Not When It Comes To the Kidney and Liver
Stefan Somlo, M.D., C.N.H., Long Professor of Medicine and Genetics
The most common potentially fatal inherited human disease is one you may never have heard of. Polycystic kidney and liver disease (PKD) affects over 600,000 individuals in the US and over 12 million worldwide. It accounts for 5-8% of dialysis and kidney transplants, and currently there is no treatment. Growth of large fluid filled cysts throughout the kidney and liver disrupt the beautiful and intricate architecture of these organs. PKD highlights the poorly understood biological process whose role is to maintain normal organ structure-without such “care and feeding” our organs would progressively deform. To gain insight into these processes, our laboratory identified several of the defective genes from patients and families and dissected their function through a combination of genetic and cell biological approaches. Our session will highlight the processes by which we have gone from discovering new genes in human diseases to understanding their functions and then returning to patients to develop therapies. We will highlight the interdisciplinary nature of this work with other Yale faculty present to answer questions and engage in discussion and tour the laboratory and demonstrate some of the more visual techniques (e.g., microscopy, cell culture, expression of proteins) that we use in our work. You will meet and speak with trainees in the laboratory who are directly engaged in advancing this field. We will also highlight how advances in large scale sequencing of human chromosomes are ramping up our pace for discoveries.


Neuroegeneration and Repair of the Brain and Spinal Cord
Steve Strittmatter, Vincent Coates Professor of Neurology
Our long term goal is to translate molecular understanding of neurodegeneration
and nerve fiber growth into therapeutic options for currently untreatable neurological diseases. Today, no medical intervention exists to promote neurological recovery after Spinal Cord Injury or Stroke. Existing therapies for degenerative diseases, such as Alzheimer's Disease, fail to alleviate, or even modify, the underlying pathophysiology. In order to make progress in these areas, we utilize cell imaging and molecular techniques to observe the degeneration and regrowth specific components of nerve cells, termed axons and dendrites. It is crucial to observe cellular changes by continuous imaging of the neurons of living organisms, and the methods of such imaging will be demonstrated in the workshop.

Stem Cells and Regenerative Medicine: Progress and Prospect
Haifan Lin, Professor & Director, Yale Stem Cell Center
This session will provide an opportunity to learn more about stem cell research, which is on the verge of a major breakthrough, promising new therapies for conditions like diabetes, Parkinson's and heart diseases. What is the latest and what's around the corner?


Yale Eye Center: Realizing the Vision
James C. Tsai, M.D., M.B.A., Robert R. Young Professor and Chair, Department of Ophthalmology and Visual Science
Comprehensive review of the exciting advances in clinical care, research, and medical education in ophthalmology at Yale University. Learn about the cutting edge medical technologies and innovative research in vision care at the Yale Eye Center. Involves an informational session and discussion with the Chair, as well as tours of the new clinical center at the Temple Medical Building and the basic science research facilities at the 300 George Building.


AYA Expo: A Reception and Fair of AYA Programs - 5:15-6:30 p.m.
After an exciting day learning about the Medical School and the latest advances in medical care, come together with other delegates and Assembly guests to enjoy an informal reception while browsing the AYA Program Fair. Learn from your fellow alumni leaders about the wide array of exciting initiatives and organizations that are changing the lives of alumni and communities across the globe! Representatives will be on hand to answer your questions about how to get involved in everything from local activities with Shared Interest Groups and the Yale Day of Service to international travel programs with Yale Educational Travel, the Yale Alumni Service Corps and the Yale Global Alumni Leadership Exchange. As an alumni leader and delegate to the AYA Assembly, you may be familiar with some of these aspects of alumni engagement, but we invite you to browse the several information booths to collect ideas to energize your constituent base.

This evening, you are invited to take advantage of one of New Haven's many award winning restaurants for dinner on your own. Continue the conversations you started during the day with other alumni leaders and friends. Information on local restaurants can be found at and will also be available at registration when you arrive for the Assembly in New Haven.


Friday, November 12

Board Interest Breakfast - 8:00 a.m.
The AYA will host a special breakfast for those interested in learning more about service on the Board of Governors.  Service on the Board of Governors a wonderful opportunity to continue a delegate's volunteer engagement. Because the AYA Board of Governors Nominating Committee gives particular consideration to delegates with some experience, the session will be especially helpful to delegates in the second or third year of their delegate term.


In the summer of 2006, the AYA Board of Governors launched a strategic planning effort designed to guide the Association over the next five years to create more ambitious programs that would serve alumni more successfully and support them more effectively in service to Yale. In 2008, the Board of Governors approved and endorsed the strategic plan. Sessions offered throughout the day on Friday are specially designed to update you on the plan and its implementation strategy, and to afford you the opportunity to brainstorm about major initiatives. 
Update: The AYA Strategic Plan with Mark Dollhopf '77, Executive Director of the AYA - 9:15-10:45 a.m.
At its heart, the AYA is about serving and engaging alumni, and advancing the needs of Yale. As Yale becomes truly global in its reach, influence, and impact, the opportunities to engage with alumni and promote the interests of the university around the world are unprecedented.

The AYA's most important asset, and the focus of the strategic plan, is you, the volunteer. You are the leaders that Yale trained; you are change agents in a changing world. The AYA is evolving to better support you in your lifelong pursuit of knowledge and enlightenment to effect that change. At the same time, if you believe that Yale can make a difference in this world, the AYA is providing you with the opportunities to advance and promote the work of this great institution.

It starts with a vision, a vision of enabling the best of Yale to be the best for Yale. This session is an opportunity to learn how the strategic plan is being implemented and to see the ways in which it is changing how alumni engage with the University and the world beyond. You will have the opportunity to share in the discussion about these ideas and AYA's strategic direction.


Alumni Leadership Awards - 10:45-11:15 a.m.
The Alumni Leadership Awards, chosen by the AYA staff, recognize the extraordinary accomplishments of alumni volunteers as Ambassadors for Yale, nominating outstanding volunteers who have demonstrated passion for their willingness to give back, a penchant for innovation and out-of-box thinking, and selfless service to Yale. Join us as we announce the award winners for 2009-2010.
The AYA Board of Governors is also proud to present the inaugural AYA Board of Governors Awards of Excellence for alumni groups and organizations that have excelled in various categories. These awards recognize the superior accomplishments of Yale classes, regional clubs and associations, shared identity and interest groups, and the graduate and professional school alumni associations. Awards will recognize events, programs, and best practices in alumni relations efforts that exhibit excellence in results and the commensurate benefits for Yale and on behalf of Yale.


Day of Service 2011 Photo - 11:15-11:30 a.m.
Don your new Yale Day of Service 2011 tee shirts (which will be provided at the morning plenary) and come together for a group shot to be used for promoting this year's Yale Day of Service to be held on May 14, 2011.


Lunch in Commons
University Update with President Richard C. Levin '74 Ph.D.
11:45 a.m.-1:15 p.m.

At lunch, Assembly attendees will be joined by those volunteers on campus for the Alumni Fund Convocation for a University Update from President Levin. Assembly and Convocation participants will have the opportunity to submit questions for President Levin during the Friday morning plenary sessions.

Leadership Development Workshops and Board/Task Force Meetings - 1:30-4:00 p.m.
How can the initiatives of the Strategic Plan invigorate your constituency's work for Yale? Attendees will break out by interest, constituency and/or activity for hands-on leadership training in bringing the goals of the strategic plan to life within your own Yale communities. In addition, meetings will be held for Task Forces and boards, as listed below. These meetings are intended for task force/board members only.

-  Yale College Class Leadership
-  Yale Clubs and Associations
-  Shared Interest Groups
-  Graduate School Alumni Association (annual fall meeting)
-  Major Cities (Boston, Chicago, Los Angeles, New Haven, New York City, San Francisco and Washington, DC)
-  Yale Day of Service
-  Yale Alumni Service Corps-Task Force Meeting (by invitation only)
-  YaleGALE
-  Bulldogs Across America (Cleveland, Denver, Houston, Louisville, Minneapolis, New Orleans, St. Louis, San Francisco, Santa Fe)


Sterling Memorial Library
Reception begins - 6:00 p.m.

For more than 50 years, the Yale Medal has been conferred to honor outstanding individual service to the University. This year's recipients reflect the range of service and leadership the AYA strives to recognize with this award. We honor the remarkable contributions of the Medalists and recognize that they honor Yale and all of us in the alumni community by the ways in which they have chosen to give back to our community of scholars and friends. We hope all Assembly participants will join us for a gala celebration honoring this year's Medalists are

-  J. Kenneth Brody '44, '49 llb
-  Susanna E. Krentz '80
-  James Leitner '75
-  Bobbi Mark '76
-  Ambassador Joseph Verner Reed '61.

For more information about the Yale Medal and this year's recipients, please go to


Saturday, November 13

While the Assembly is offcially over, we are pleased to provide you with information on the following activities for Saturday.

Yale Center for British Art -10:00 a.m.-5:00 p.m.
A guided Tour of the Center's architecture begins at 11 a.m., and at 2 p.m. there will be a student-led introductory tour of the Center with diverse themes. Both tours meet at the information desk. Special exhibits include Notes from the Archive: James Frazer Stirling, Architect and Teacher (you may take a tour of this exhibit beginning at 1 p.m., meeting at the information desk) and The Independent Eye: Contemporary British Art from the Collection of Samuel and Gabrielle Lurie.


Yale University Art Gallery -10:00 a.m.-5:00 p.m.
Guided Masterpiece Tours are available at 1:30 p.m.; gather at the front desk. Special exhibits include John La Farge's Second Paradise: Voyages in the South Seas, 1890-1891.


Yale-Princeton Football Game
Please note that alumni can take advantage of the free transportation to the Yale Bowl provided by Athletics. Shuttle busses leave from in front of the Payne Whitney Gym beginning at 9:00 a.m. and shuttle continuously to and from the Yale Bowl. To return to campus, get the shuttle back on Yale Avenue by Gate B; bus service ends at approximately 5:00 p.m.


Pre-Game AYA Hospitality Tent -10:00 a.m.-12:00 noon
We invite you to join the AYA and your classmates and friends for our exciting pre-Game event at the Yale Bowl. Once again the AYA will be hosting the very popular hospitality tent, AYA Alumni Village, located within the Hospitality Village adjacent to the Yale Bowl. This free event for all alumni provides a place to gather and meet up with classmates before going to the game. Free refreshments and raffles for those who come early!


Yale-Princeton Football Game - Kick-off 12:00 noon
Assembly participants are invited to attend the Yale-Princeton game at the Bowl. Mark your registration form if you wish to receive complimentary tickets (up to two) for admission to the game. You may also purchase additional tickets at the price of $8 each.